瑞博域名

等温滴定量热仪（Isothermal Titration Calorimetry）

型号：MicroCal? iTC200

中文介绍：

ITC是一种通用属性技术（测量热量），广泛应用于二次筛选/hit 验证中快速得到 KD 值，指导优化和表征分子间作用机理。 它还可以用于验证常用参数IC50和EC50的值。 IC50是最大抑制浓度的一半，是化合物在抑制生物学或生化功能中的有效量度。 EC50，是最大有效浓度的一半，通常用作药物效力的量度。 此外，ITC可用于测量和量化涉及热变化的任何过程，例如酶促反应。

英文介绍：

ITC is a universal property technique (measure heat) and thus is used across a wide range of applications from measuring affinity values for secondary screening confirmation of hits and hit validation to guiding lead optimization and characterizing mechanism of action. It?s also used to validate the values of the commonly used parameters IC50 and EC50. Briefly you can say that IC50 is the half maximal inhibitory concentration and is a measure of the effectiveness of a compound in inhibiting biological or biochemical function. It is comparable to EC50 which is the half maximal effective concentration, commonly used as a measure of drug?s potency. Furthermore, ITC can be used to measure and quantify any process that involves a heat change, such as an enzymatic reaction.