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College of Biological Science and Engineering

袁彩

发布日期:2022-02-23 发布者:

姓名:袁彩

性别:


职称:研究员

学历:博士

电话:0591-22867972

电子邮件:cyuan@fzu.edu.cn

研究方向:结构生物学、生物化学与分子生物学

教育工作经历:

2022.1- 宝博网页版登录界面            研究员

2016.06-2021.12 宝博网页版登录界面      副研究员

2011.01-2016.06 中国科学院福建物质结构研究所     副研究员

2010.06-2011.06 哈佛大学医学院             访问学者

2005.04-2010.12 中国科学院福建物质结构研究所     助理研究员

2005.03-2008.07 中国科学院福建物质结构研究所     生物化学与分子生物学 博士

2003.07-2005.04 中国科学院福建物质结构研究所     研究实习员

2000.09-2003.07 福建师范大学 生物化学与分子生物学  硕士

1995.08-2000.08 福建省福安市赛岐中学          中学老师

教学简介:

本科生课程《蛋白质化学与工程》,研究生课程《蛋白质结构与现代药物开发》。指导研究生获得福州大学优秀学位论文。

科研简介:

主要从事蛋白的结构和功能研究,并基于结构进行多肽和蛋白类药物的改造和评价。目前已发表SCI论文六十余篇,先后主持国家自然科学基金面上项目,教育部留学回国人员科研启动基金项目及福建省自然科学基金项目。主要研究领域包括:

1、肿瘤迁移相关蛋白的结构和功能研究:几乎90%癌症病人的死亡是由于癌细胞的转移性扩散引起。目前针对原发性肿瘤的治疗卓有成效,但靶向肿瘤转移方面的进展却不尽人意。我们主要针对肿瘤迁移相关的一些蛋白如尿激酶受体系统和多种丝氨酸蛋白酶,及其与抑制剂的复合物进行X-射线晶体结构研究,并针对这些结构指导抑制剂的改造,以发展高效特异的肿瘤治疗药物。

2、血栓形成相关蛋白的结构和功能研究:人体保持血液处于正常流动状态,主要依赖于凝血系统和纤溶系统处于一个动态平衡。病理条件下两个系统的功能异常将导致出血或血栓形成。我们针对凝血和纤溶相关的一些蛋白如纤溶酶原激活物tPA、多种凝血因子及它们的调控蛋白PDI进行结构和功能的研究,并基于这些结构进行抑制剂的设计和改造,以发展高效且无出血副作用的溶栓和抗血栓形成药物。

3、光动力抗肿瘤和抗菌研究:光敏剂在特定波长的光激发下可产生具有生物毒性的单线态氧或者自由基,进而杀死细胞或微生物,可用于抗肿瘤和抗菌方面的治疗。传统的光敏剂存在靶向性差,水溶性不佳等问题。我们对光敏剂进行一系列的修饰和包裹,发展高靶向性光敏剂,用于抗肿瘤和耐药菌的治疗。

社会兼职:

主持的科研项目:

1.国家自然科学基金面上项目,内吞性胶原蛋白受体Endo180的结构研究(31570745),2016.01-2019.12

2.国家自然科学基金面上项目,肝细胞生长因子激活物抑制剂1的结构研究(31170707),2012.1-2015.12

3.国家自然科学基金面上项目,基质降解相关蛋白的结构研究(30770429),2008.1-2010.12

4.福建省自然科学基金(面上),基于结构的PDI抑制剂设计及其抗血栓活性研究,(2018J01897),2018.04-2021.04

5.福建省青年创新项目,基质胰酶及其抑制剂的结构研究(2009J05091),2009.1-2011.12

6.教育部留学回国人员科研启动基金,肝细胞生长因子激活物抑制剂1的结构生物学及分子机理研究(教外司留2013693)2013-2015

近五年代表性论文:(*为通讯作者)

1.Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Longguang Jiang, Yingping Cao, Liqing Chen,Cai Yuan*, Mingdong Huang*. Crystal Structure and Cellular Functions of uPAR Dimer. Nature communications, 2022, 13:1665. https://doi.org/10.1038/s41467-022-29344-y

2.Chenghui Liang, Robert Flaumenhaft,Cai Yuan*, Mingdong Huang*. Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug Discovery Today, 2022, 27(2), 626-635. doi:10.1016/j.drudis.2021.10.018

3.Zhiwei Huang, Huajian Lin, Shujuan Yu, Hanlin Li, Yang Zhou, Yuan Cheng, Shanli Chen,Cai Yuan*, Mingdong Huang*. A versatile insertion point on albumin to accommodate peptides and maintain their activities. International journal of biological macromolecules, 2022, 205, 49-54. doi:10.1016/j.ijbiomac.2022.02.002

4.Shanli Chen, Dan Chen, Yurong Liu, Yanyan Xu, Huajian Lin, Yuan Cheng, Jinyu Li, Chun Meng, Mingli Liang,Cai Yuan*, Mingdong Huang*. Enhanced clot lysis by a single point mutation in a reteplase variant. British Journal of Haematology, 2022, 196(4), 1076-1085. doi:10.1111/bjh.17942

5.Di Zhang, Jingyi Chen, Qian Jing, Zheng Chen, Azeem Ullah, Longguang Jiang, Ke Zheng,Cai Yuan*, Mingdong Huang*. Development of a Potent Antimicrobial Peptide With Photodynamic Activity. Frontiers in Microbiology, 2021, 12. doi:10.3389/fmicb.2021.624465

6.Cai Yuan, Zhanzhi Guo, Shujuan Yu, Longguang Jiang*, Mingdong Huang*. Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discovery Today, 2021, 26(4), 1076-1085. doi:10.1016/j.drudis.2021.01.016

7.Shujuan Yu, Gaohui Sun, Yaqun Sui, Hanlin Li, Yuhan Mai, Guodong Wang, Ning Zhang, Yuhai Bi, George F. Gao, Peng Xu, Longguang Jiang,Cai Yuan*, Yang Yang*, Mingdong Huang*. Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds. Dyes and Pigments, 2021, 194. doi:10.1016/j.dyepig.2021.109570

8.Linlin Li, Mingxiang Huang, Jianshan Shen, Yao Wang, Rui Wang,Cai Yuan*, Longguang Jiang, Mingdong Huang. Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity. Journal of Infectious Diseases, 2021, 223(1), 178-179. doi:10.1093/infdis/jiaa642

9.Longguang Jiang,Cai Yuan*, Mingdong Huang*. A general strategy to inhibit serine protease by targeting its autolysis loop. Faseb Journal, 2021, 35(2). doi:10.1096/fj.202002139RR

10.Libin Jiang, Yunbin Jiang, Linlin Li, Ke Zheng, Shujuan Yu, Jinyu Li,Cai Yuan*, Mingdong Huang*. A supramolecular nanocarrier for efficient cancer imaging and therapy by targeting at matriptase. Journal of Controlled Release, 2021, 334, 153-163. doi:10.1016/j.jconrel.2021.04.019

11.Linlin Li, Dan Chen, Ke Zheng, Libin Jiang, Tao Dai, Ling Yang, Longguang Jiang, Zhuo Chen,Cai Yuan*, Mingdong Huang*. Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. Acs Applied Materials & Interfaces, 2020, 12(4), 4221-4230. doi:10.1021/acsami.9b18396

12.Yunbin Jiang, Lin Lin*, Shanli Chen, Longguang Jiang, Mette C. Kriegbaum, Henrik Grdsvoll, Line V. Hansen, Jinyu Li, Michael Ploug,Cai Yuan*, Mingdong Huang*. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain. International Journal of Biological Sciences, 2020, 16(6), 981-993. doi:10.7150/ijbs.39919

13.Libin Jiang, Yurong Liu, Xianyuan Xu, Dan Su, Huasong Zou, Jianyong Liu,Cai Yuan*, Mingdong Huang*. Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation. Frontiers in Microbiology, 2020, 11. doi:10.3389/fmicb.2020.571691

14.许燕艳,陈珊莉,陈丹,彭双周,程媛,李金宇,李永坤,江龙光,袁彩*,黄明东*.缺血性脑卒中溶栓药物研究进展.生物工程学报, 2020, 36(10), 2029-2039. doi:10.13345/j.cjb.200107

15.梁程辉,陈丹,廖馨源,江龙光,袁彩*,黄明东*.蛋白质二硫键异构酶的结构及抑制剂研究进展.生物化学与生物物理进展, 2020, 47(07), 595-606. doi:10.16476/j.pibb.2020.0065

16.Le Shang, Guangpu Xue, Lihu Gong, Yaxin Zhang, Shuangzhou Peng,Cai Yuan*, Mingdong Huang*. A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent. Analytica Chimica Acta, 2019, 1053, 98-104. doi:10.1016/j.aca.2018.12.005

17.Min Liu#, Lin Lin#, Gunilla Hoyer-Hansen, Michael Ploug, Hanlin Li, Longguang Jiang,Cai Yuan*, Jinyu Li*, Mingdong Huang*. Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Febs Letters, 2019, 593(11), 1236-1247. doi:10.1002/1873-3468.13397

18.Rui Li, Chenghui Liang, Longguang Jiang,Cai Yuan*, Mingdong Huang*. Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications, 2019, 510(4), 539-544. doi:10.1016/j.bbrc.2019.01.102

19.Dafeng Liu, Linsen Li, Jincan Chen, Zhuo Chen, Longguang Jiang,Cai Yuan*, Mingdong Huang*. Dissociation of zinc phthalocyanine aggregation on bacterial surface is key for photodynamic antimicrobial effect. Journal of Porphyrins and Phthalocyanines, 2018, 22(9-10), 925-934. doi:10.1142/s1088424618500888

20.Shijie Li, Linlin Li, Zhuo Chen, Guangpu Xue, Longguang Jiang, Ke Zheng, Jincan Chen, Rui Li,Cai Yuan*, Mingdong Huang*. A novel purification procedure for recombinant human serum albumin expressed in Pichia pastoris. Protein Expression and Purification, 2018, 149, 37-42. doi:10.1016/j.pep.2018.04.012

21.Min Liu,Cai Yuan*, Yunbin Jiang, Longguang Jiang, Mingdong Huang*. Recombinant hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2 cells, purification and crystallization. Acta Crystallographica Section F-Structural Biology Communications, 2017, 73, 45-50. doi:10.1107/s2053230x16020082

22.Min Liu,Cai Yuan*, Jan K. Jensen, Baoyu Zhao, Yunbin Jiang, Longguang Jiang, Mingdong Huang*. The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition. Journal of Biological Chemistry, 2017, 292(20), 8412-8423. doi:10.1074/jbc.M117.779256

23.郭团玉,赵宝玉,袁彩*,黄明东*.丝氨酸蛋白酶催化结构域无活性突变体的表达、纯化与结晶].过程工程学报, 2017, 17(4), 834-838.

24.Shanli Chen#, Lin Lin#,Cai Yuan*, Henrik Gardsvoll, Mette C. Kriegbaum, Michael Ploug, Mingdong Huang*. Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor. Acta Crystallographica Section F-Structural Biology Communications, 2017, 73, 486-490. doi:10.1107/s2053230x17009748

25.Xiaolei Zhou, Mingming Xu, Hailong Huang, Andrew Mazar, Zafar Lqbal,Cai Yuan*, Mingdong Huang*. An ELISA method detecting the active form of suPAR. Talanta, 2016, 160, 205-210. doi:10.1016/j.talanta.2016.07.004

26.Cai Yuan, Henrik J. Jurgensen, Lars H. Engelholm, Rui Li, Min Liu, Longguang Jiang, Zhipu Luo, Niels Behrendt, Mingdong Huang*. Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding. Biochemical Journal, 2016, 473, 2359-2368. doi:10.1042/bcj20160276

获奖情况

其他

研究生招生专业:生物医学工程、生物工程、生物技术工程;欢迎有志从事科研工作的硕士生报考我们课题组。

课题组介绍:http://fmerc.fzu.edu.cn/html/rcdw/hmdktz/1.html

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