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College of Biological Science and Engineering

杨丽聪

发布日期:2021-04-27 发布者:宝博网页版登录界面

   

姓名:杨丽聪

性别:女





职称:副教授/硕士生导师

学历:博士

电子邮件:wanttobea@163.com


研究方向:食品源多酚资源开发、纳米材料制备及活性研究

教育工作经历:

2021.03-至今:福州大学,副教授

2018.11-2021.2:江西农业大学,副教授,青年教授

2015.07-2018.11:江西农业大学,讲师,未来之星

2012.09-2015.06:暨南大学,生物化学与分子生物学,博士

教学简介:

曾主讲本科生课程《食品毒理学》,《食品生物化学》、《食品酶工程》等。教学评估中曾获得校级“优秀一等”荣誉。

科研简介:

从事食品源植物多酚生物资源开发利用、纳米材料制备及其在阿尔兹海默症治疗、降脂减肥等领域的研究工作。已先后主持国家自然科学基金项目、江西省自然科学基金项目、和江西省教育厅科技项目等6余项,并作为主要成员参与国家基金、中央财政农业技术推广经费项目、江西省自然科学基金及江西省教育厅科学技术研究项目等7余项。在纳米材料、生物化学、食品营养等领域国际高水平SCI期刊Acta Biomaterialia、Nanoscale 、Journal of Materials Chemistry B、Journal of Functional Foods、European Journal of Nutrition、Food Function和Biomaterials等发表论文30余篇。申请发明专利7件,授权发明专利4件。


主要科研项目:

主持课题

1. 国家自然科学地区基金项目,21967010,基于不同负载作用力二氢杨梅素纳米载药体系的构建及其抑制阿尔兹海默症的研究,2020/01-2023/12,40万元,在研,主持

2. 国家自然科学青年科学基金项目,21701068,多酚纳米硒多肽靶向抑制Aβ聚集及减缓氧化应激活性的研究,2018/01-2020/12,23万元,结题,主持

3. 江西省教育厅科学技术研究项目,GJJ180209,绿原酸纳米多肽靶向透过血脑屏障抑制Aβ聚集的研究,2019/01-2020/12,3万元,结题,主持

4. 江西省高校教改立项资助项目,JXJG-16-3-15,食品毒理学教学改革研究,2017/01-2019/ 12,5000元,结题,主持

5. 江西省科技计划项目自然科学基金,20171BAB215074,白藜芦醇修饰的纳米硒抑制阿尔兹海默症中Aβ聚集及自由基生成的研究,2017/01-2018/12,6万元,结题,主持

6. 江西省教育厅科学技术研究项目,GJJ160383,绿原酸修饰纳米硒抑制Aβ聚集的体外研究,2017/01-2018/12,3万元,结题,主持

参与课题

1. 第二参与人,中央财政农业技术推广经费项目永新县优质茶叶生产示范推广项目研发经费,2018ZDF40010-5,2020/01-2020/12,5万元,结题;

2. 第二参与人,国家自然科学基金,81760157,基于AMPK信号通路研究菝葜黄酮调控脂类代谢分子机制,2018/01-2021/12,32万元,在研;

3. 第二参与人,国家自然科学基金,31760461,龟苓膏中黄酮“落新妇苷”与蛋白质相互作用机制及对其稳定性和生物利用度的影响,2018/01-2021/12,38万元,在研;

4. 第三参与人,国家自然科学基金,31660486,新型抗A0Z/AMOZ双特异性单链抗体的构建及其多残留同时免疫分析方法研究,2017/01-2020/12,39万元,结题;

5. 第二参与人,江西省自然科学基金项目,20142BAB204003,咖啡碱和绿原酸对高脂饮食诱导肥胖小鼠脂肪代谢相关基因和蛋白表达的影响,2014.01-2015.12,5万元,结题。

6. 第二参与人,江西省教育厅科学技术研究项目,GJJ160414,天然紫色杆菌素(Violacein) 微生物生成能力的关键蛋白结构的研究,2017/01-2018/12,2万元,结题;

7. 第三参与人,江西省教育厅科学技术研究项目(项目编号GJJ160415):基于纳米抗体的Cry1Ac蛋白免疫传感器检测性能的研究,2017/01-2018/12,2万元,结题;

代表性论文及专利:(*为通讯作者,#为共同第一作者)

科研论文

  1. Changjiang Li, Na Wang, Guodong Zheng*, and Licong Yang*,Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota. ACS Applied Materials & Interfaces  2021, 13, 39, 46406-46420.

  2. Xin Li#, Licong Yang#, Meng Xu, Gaoxiang Qiao, ChangJiang Li, Lezhen Lin, Guodong Zheng *. Smilax china L. polyphenols alleviates obesity and inflammation by modulating gut microbiota in high fat/high sucrose diet-fed C57BL/6J mice. Journal of Functional Foods. 2021, 77, 104332. 

  3. Licong Yang, Yanping Zhu, Shusheng Zhong and Guodong Zheng*. Astilbin lowers the effective caffeine dose fordecreasing lipid accumulation via activating AMPK in high-fat diet-induced obese mice. Journal of the Science of Food and Agriculture. 2020, 101(2), DOI: 10.1002/jsfa.10669.

  4. 李长江,朱珊珊,王娜,聂梦娇,郑国栋*,杨丽聪*。Vc@SeNPs抗氧化活性评价及其对鲜切苹果品质的影响,食品与发酵工业,2020, 46(13):174-181.

  5. 李欣,潘永芳,王娜,杨丽聪*,郑国栋*。菝葜醇提物对小鼠脂肪代谢酶的影响,江西农业大学学报,2020,42(02):385-390.

  6. Licong Yang, Yan Zhao, Yongfang Pan, Dongming Li and Guodong Zheng*. Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice. Nutrition & Metabolism. 2019, 16:6.  

  7. Meng Xu#, Licong Yang#, Yanping Zhu, Mingfu Liao, Lulu Chu, Xin Li, Lezhen Lin, Guodong Zheng*. Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKα-LXRα/SREBP-1c pathway in high-fat diet-induced obese mice. Food Function. 2019, 10, 7489-7497.   

  8. Meng Xu, Hui Xue, Xin Li, Yan Zhao, Lezhen Lin,Licong Yang*, Guodong Zheng*. Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols. Applied Microbiology and Biotechnology. 2019, 103(21), 9013-9022.  

  9. Lulu Chu, Licong Yang*, Lezhen Lin, JingWei, NaWang, Meng Xu, Gaoxiang Qiao, Guodong Zheng*. Chemical composition, antioxidant activities of polysaccharide from Pine needle (Pinus massoniana) and hypolipidemic effect in high-fat diet-induced mice. International Journal of Biological Macromolecules. 2019, 125: 445-452.  

  10. Lulu Chu, Licong Yang*, Jingen Li, Lezhen Lin, Guodong Zheng*. Effect of Smilax china L. starch on the gel properties and interactions of calcium sulfate-induced soy protein isolate gel. International Journal of Biological Macromolecules. 2019, 135(15), 127-132.  

  11. 王娜,褚路路,徐梦,乔高翔,郑国栋,杨丽聪*。没食子酸修饰纳米硒的制备表征及其抑菌活性研究。食品科技,2019,44(01):302-307.

  12. Licong Yang,Wenjun Wang, Jiguang Chen, Na Wang, Guodong Zheng*. A comparative study of resveratrol and resveratrol-functional selenium nanoparticles: inhibiting amyloid β aggregation and reactive oxygen species formation properties. Journal of Biomedical Materials Research Part A. 2018, 106(12): 3034-3041. A1二区 IF=3.231

  13. Licong Yang, Na Wang, Guodong Zheng*. Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro Nanoscale Research Letters. 2018, 13:303. A1二区 IF=3.125

  14. Jiluan Liu#, Licong Yang#, Xiaojuan Zhu, Wejun Wang and Guodong Zheng*, Combinational Effect of Pine Needle Polysaccharide and Kudzu Flavonoids on Cell Differentiation and Fat Metabolism in 3T3-L1 Cells. Food Science and Technology Research. 2018, 24: 903-910.  

  15. Licong Yang, Tiantian Yin, Yanan Liu, Jing Sun, Yanhui Zhou and Jie Liu*. Gold nanoparticle-capped mesoporous silica-based H2O2-responsive controlled release system for Alzheimer’s disease treatment. Acta Biomaterialia. 2016, 46, 177-190.

  16. Licong Yang, Jing Sun, Wenjie Xie, Yanan Liu and  Jie Liu*. Dual-functional selenium nanoparticles bind to and inhibit amyloid β fiber formation in Alzheimer's disease. Journal of Materials Chemistry B. 2017, 5, 5954-5967.

  17. Zhao Yan#, Yang Licong#, Huang Zhangwang, Lin Lezhen and Guodong Zheng, Synergistic effects of caffeine and catechins on lipid metabolism in chronically fed mice via the AMP-activated protein kinase signaling pathway. European Journal of Nutrition. 2017, 56: 2309-2318.  

  18. Licong Yang#, Qingchang Chen#, Ying Liu, Jingnan Zhang, Dongdong Sun, Yanhui Zhou and Jie Liu*. Se/Ru nanoparticles as inhibitors of metal-induced Aβ aggregation in Alzheimer’s disease. Journal of Materials Chemistry B. 2014, 2, 1977-1987.

  19. Qingchang Chen#, Licong Yang#, Chuping Zheng, Wenjing Zheng, Jingnan Zhang, Yunshan Zhou and Jie Liu*. Mo polyoxometalate nanoclusters capable of inhibiting the aggregation of Aβ-peptide associated with Alzheimer's disease. Nanoscale. 2014, 6(12):6886-6897.

  20. Licong Yang, Jingnan Zhang, Chuan Wang, Xiuying Qin, Qianqian Yu, Yanhui Zhou* and Jie Liu*. Interaction between 8-hydroxyquinoline ruthenium(II) complexes and basic fibroblast growth factors (bFGF): inhibiting angiogenesis and tumor growth through ERK and AKT signaling pathways.Metallomics. 2014, 41, 1734-1741.  

  21. 杨丽聪,郑国栋*, 蒋 艳,尹忠平,徐明生。咖啡碱与茶多酚组合对小鼠肝脏脂肪代谢酶活性的影响。 中国食品学报。2011,3:14-19。

  22. 杨丽聪,郑国栋 *,王纯荣,黎冬明。咖啡碱与儿茶素组合对小鼠体重和脂类代谢的影响。茶叶科学。2010,30(5):374~378.

  23.  Xiu Ying Qin, Licong Yang, Fang Ling Le, Qian Qian Yu, Dong Dong Sun, Ya Nan Liu and Jie Liu*. Structures and Anti-cancer Properties of Two Binuclear Copper Complexes. Dalton Transactions. 2013, 42(41):14681-14684.

  24. Wenjing Zheng; Licong Yang; Ying Liu; et al. Mo polyoxometalate nanoparticles inhibit tumor growth and vascular endothelial growth factor induced angiogenesis. Science and Technology of Advanced Materials, 2014,15 (3).

  25. Xiu-Ying Qin, Ya-Nan Liu, Qian-Qian Yu, Li-Cong Yang, Ying Liu, Yan-Hui Zhou,* and Jie Liu*. Mixed-Ligand Mononuclear Copper(II) Complex: Crystal Structure and Anticancer Activity. ChemMedChem. 2014, 9(8):1665-71.

  26. Jingnan Zhang, Xianbo Zhou, Qianqian Yu, Licong Yang, Dongdong Sun, Yanhui Zhou, and Jie Liu*. Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet-1 Peptide To Reduce Amyloid-β Aggregation and Cytotoxicity. ACS Appl Mater Interfaces. 2014, 6, 8475-8487.

  27. Ying Liu, Yanan Liu, Licong Yang, Chengwen Cao, Yanhui Zhou and Jie Liu*. Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes. Med. Chem. Commun., 2014, 5, 1724-1728.

  28. Dongdong Sun, Yanan Liu, Qianqian Yu, Xiuying Qin, Licong Yang, Yanhui Zhou, Lanmei Chen, Jie Liu*. Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles. Biomaterials. 2014, 35(5):1572-1583.

  29. Qian Li, Jingnan Zhang, LicongYang, Qianqian Yu, Qingchang Chen, Xiuying Qin, Fangling Le,Qianling Zhang, JieLiu*. Stabilization of G-quadruplex DNA and inhibition of telomerase activity studies of ruthenium(II) complexes. Journal of Inorganic Biochemistry. 2014,130: 122-129.

  30. Jingnan Zhang, Qianqian Yu, QianLi, LicongYang, LanmeiChen, YanhuiZhou*, Jie Liu*. A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor. Journal of Inorganic Biochemistry, 2014,134: 1-11.

  31. Chuan Wang, Qianqian Yu, Licong Yang, Yanyu Liu, Dongdong Sun, Yongchao Huang, Yanhui Zhou, Qianling Zhang and Jie Liu. Ruthenium (II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells. Biometals. 2013, 26(3):387-402.

已授权专利4

(1) 杨丽聪,郑国栋。一种兼具抑制Aβ多肽聚集及清除活性氧的纳米粒子制备方法和应用,国家知识产权局,专利号:ZL201810727969.7。

(2)刘杰,杨丽聪,专利:抑制Aβ及金属离子诱导其聚集的纳米粒子及制备和应用,国家知识产权局,专利号:ZL201410150890.4。

(3) 刘杰,杨丽聪,尹田田,周艳晖。专利:一种金属有机框架负载药物及其制备方法和应用,国家知识产权局,专利号:ZL201510279930.X。

(4) 刘杰,杨丽聪,周艳晖。专利:一种负载CQ的纳米金封堵介孔二氧化硅控制释放系统及其制备方法和应用,国家知识产权局,专利号:ZL201510271819.6。

正在申请专利3项

(1) 杨丽聪,郑国栋,李长江,王亚彬,梁瀚吉,黎志伟。二氢杨梅素纳米硒及其制备方法和应用。申请号:202011350451.X。

(2) 郑国栋,杨丽聪,林乐珍。专利:一种菝葜醇提物在制备减肥降脂药物中的应用。申请号:201510877843.4。

(3) 郑国栋,杨丽聪,金伟丽,林乐珍。一种抑制黄嘌呤氧化酶活性的菝葜提取物制备方法和应用。申请号:201810728114.6。


               

           

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