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College of Biological Science and Engineering

张芳

发布日期:2022-02-25 发布者:

姓名:张芳

性别:

职称:副教授

学历:博士

研究方向:快速检测方法的开发,涉及纳米材料功能化、生物传感器设计、核酸适配体、恒温扩增技术等技术领域。

电子邮件:fangzh921@fzu.edu.cn

教育工作经历:

2022/01— 至今     福州大学,宝博网页版登录界面,副教授

2016/042021/12   福州大学,宝博网页版登录界面,讲师

2019/032020/11     Chemistry, University of Waterloo, 博士后

2012/092016/03     浙江大学,生物系统工程与食品科学学院,博士

2014/122015/06     英国伦敦大学学院,纳米技术与再生医学中心,访问学者

2009/092012/07     福建农林大学,食品科学与工程学院,硕士

教学简介:

研究生课程:《海洋生物资源开发与利用》、《现代仪器分析》和《食品生物技术》

本科生课程:《食品微生物》、《食品工厂设计》

科研简介:

目前主要从事生物与纳米技术交叉领域的应用研究,主持国家自然科学基金(面上)、国家自然科学基金(青年)、福建省自然科学基金(面上)、福州市校(院所)科技合作项目、福建省教育厅中青年教育科研项目及校级科研启动项目6项,承担企业横向课题1项,并参与国家自然科学基金海峡联合重点基金1项、国家重点研发计划项目1项。已在包括Anal. Chem.、 Chem. Comm.、J. Agr. Food Chem.、Food Chem.、Food Hydrocolloid.、ACS sensors、Langmuir、Food Chem. X等在内的国际权威学术期刊发表SCI论文29篇(其中一作13篇,通讯作者5篇),获授权发明专利2项。

主要科研项目:

1.国家自然科学基金面上项目,32172285,超稳可控纳米探针协同CRISPR/Cas14高保真信号传感体系通用型抗生素检测方法研究,58万,2022/01-2025/12,在研,主持

2.国家自然科学基金联合基金项目,U1905202,闽台特色海鱼加工过程中品质形成的分子基础及调控机制,国家自然科学基金海峡联合重点基金,222万,2020/01-2023/12,在研,参与(排名第二)

3.国家自然科学基金青年科学基金项目,31701683,基于NEAR放大及发射光叠加信号分析的高灵敏可视化双食源性病毒检测方法研究,2018/01-2020/12,25万元,结题,主持    

4.国家重点研发计划现代食品加工及粮食收储运技术与装备,2016YFD0400200,食品加工过程中组分结构变化及品质调控机制研究,2016/07-2020/12,230万元,结题,参与  (排名第二)

5.福建省自然科学基金面上项目,2019J01060202,基于颜色演变(Color-evolution)和FRET的高灵敏可视化双重致病菌检测方法研究,2019/4-2022/4,10万元,结题,主持

6.一种高尔基体蛋白73检测方法(免疫磁珠)的研发,横向项目,25万元,结题,主持

7.福建省教育厅中青年教育科研项目,JAT170079,基于DNA回路的新型高特异性水产致病菌检测方法研究,2017/07-2019/09,1.5万元,结题,主持

8.福州市校(院所)科技合作项目,2017-G-64,出口鱼类制品中沙门氏菌、霍乱弧菌、副溶血性弧菌等重要水产致病菌的自检自控关键技术开发及应用推广,2017/03-2019/03,10万元,结题,主持


代表性论文:(*为通讯作者)

1. Linlin Bai, Liu Wang, Shuqin Huang, Rong Bai, Xucong Lv, Liping Sun, Fang Zhang*, Xiahong Xu*. Rapid, Visual, and Sequence-Specific Detection of Salmonella in Egg Liquid with vis-NEAA, a CRISPR/Cas12 Empowered New Strategy. Journal of Agricultural and Food Chemistry, 2022.    

2. Fang Zhang, Chenshan Gao, Linlin Bai, Yiquan Chen, Shuying Liang, Xucong Lv, Jinyuan Sun, Shaoyun Wang*. Dual-color blending based visual LAMP for food allergen detection: A strategy with enlarged color variation range and contrast. Food Chemistry: X, 2022, 13: 100201.

3. Xueyun Chen, Liu Wang, Fang He, Ganghui Chen, Linlin Bai, Kaiyu He, Fang Zhang*, and Xiahong Xu*. Label-Free Colorimetric Method for Detection of Vibrio parahaemolyticus by Trimming the G-Quadruplex DNAzyme with CRISPR/Cas12a.

Analytical Chemistry, 93 (4)2,14300-14306 (2021)

4. 白榕, 白琳琳, 汪少芸, 张芳*. LAMP扩增产物检测方法研究进展及基因编辑技术在其中的应用.农业生物技术学报, 2021, 29(10): 2016-2030.

5. Fang Zhang,Juewen Liu*. Interactions of the Cocaine and Quinine Aptamer with Gold Nanoparticles under the Dilute Biosensor and Concentrated NMR Conditions. Langmuir,2021, 37(40):11939-11947  

6. Fang Zhang, Juewen Liu*. Label‐Free Colorimetric Biosensors Based on Aptamers and Gold Nanoparticles: A Critical Review. Analysis & Sensing,1,30-43 (2021)

7. Fang Zhang, Po-Jung Jimmy Huang and Juewen Liu*. Sensing Adenosine and ATP by Aptamers and Gold Nanoparticles: Opposite Trends of Color Change from Domination of Target Adsorption Instead of Aptamer Binding. ACS Sensors, 5, 2885–2893 (2020)

8. Fang Zhang, Xixi Cai, Lan Ding, Shaoyun Wang*. Effect of pH, ionic strength, chitosan deacetylation on the stability and rheological properties of O/W emulsions formulated with chitosan/casein complexes. Food Hydrocolloids, 111, 106211 (2021)

9. Fang Zhang, Biwu Liu, Anand Lopez, Shaoyun Wang* and Juewen Liu*. Opposite salt-dependent stability of i-motif and duplex reflected in a single DNA hairpin nanomachine. Nanotechnology, 31, 195503 (2020)    

10. Fang Zhang, Shaoyun Wang* and Juewen Liu*. Gold Nanoparticles Adsorb DNA and Aptamer Probes Too Strongly, and a Comparison with Graphene Oxide for Biosensing. Analytical Chemistry, 91, 14743-14750 (2019)

11. Liang Lv, Caili Fu, Fang Zhang*, Shaoyun Wang*. Thermally-induced Whey Protein Isolate-Daidzein co-assemblies: protein-based nanocomplexes as an inhibitor of precipitation /crystallization for hydrophobic drug. Food Chemistry. 2019.275(1),273-281.        

12. Qingxia Weng, Xixi Cai, Fang Zhang*, Shaoyun Wang*. Fabrication of self-assembled Radix Pseudostellariae protein nanoparticles and the entrapment of curcumin. Food Chemistry.2019.274(15),796-802  

13. Rui Wang#, Fang Zhang#(co-first),, Cheng Qian, Cui Wu, Zunzhong Ye, Liu Wang, Wenjuan Qian, Jianfeng Ping, Jian Wu*, Yibin Ying, Counting DNA molecules with visual segment-based readouts in minutes, Chemical Communications, 2018,54(9):1105-1108.

14. Rui Wang#, Fang Zhang# (co-first), Liu Wang, Wenjuan Qian, Cheng Qian, Jian Wu*, Yibin Ying, Instant, Visual, and Instrument-Free Method for On-Site Screening of GTS 40-3-2 Soybean Based on Body-Heat Triggered Recombinase Polymerase Amplification. Analytical Chemistry,2017,89(8):4413-4418.

15. Fang Zhang, Liu Wang, Rui Wang, Yibin Ying, Jian Wu*. Simple screening strategy with only water bath needed for the identification of insect-resistant genetically modified rice. Analytical Chemistry,2015,87(3):1523-1526.

16. Fang Zhang, Rui Wang, Jian Wu*, Liu Wang, Yibin Ying. Tracing phosphate ions generated during DNA amplification and its simple use for visual detection of isothermal amplified products. Chemical Communications, 2014, 50(92): 14382-14385.

17. Fang Zhang, Jian Wu*, Rui Wang, Liu Wang, Yibin Ying. Portable pH-inspired electrochemical detection of DNA amplification. Chemical Communications, 2014,50(61):8416-8419.                      

18. Fang Zhang, Liu Wang, Kai Fan, Jian Wu*, Yibin Ying. The detection of T-Nos, a genetic element present in GMOs, by cross-priming isothermal amplification with real-time fluorescence. Analytical and Bioanalytical Chemistry. 2014,406(13):3069-3078.  


国家发明专利:

1.可视化检测核酸恒温扩增的反应装置及方法(201410431991.9),发明人:吴坚、张芳。

2.可视化检测核酸恒温扩增的反应装置(201420491668.6),发明人:吴坚,张芳



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